If you removed the tank (and assuming you don't have a valve between it and the gun) there can't be any CO2 left in the tube, unless the hole in the tank block is plugged and I have no idea how that could happen.... I suppose if both ends of the valve were plugged there could still be CO2 in the valve, but again, very unlikely....
If you find it difficult to remove the screws holding the tank block to the tube then that could be an indication there is pressure trying to push on the tank block.... If they spin out easily, and once they are loose slightly you can move (wiggle) the tank block easily it should be safe to disassemble....
Bob